The project is entitled “Universal T cell responses against pathogenic bacteria and protists”, and is financed by the Netherlands Organisation for Scientific Research (NWO). While being a basic research project, the overall goal is to contribute to alternative approaches of vaccine development. Antigen presentation by the human CD1 molecules is the central focus of the project. The specific aims are to identify new lipid antigens from Trypanosoma, Brucella, Campylobacter, Staphylococcus, Salmonella, and Coxiella, identify and characterize the human T cells that respond to these lipids, analyze their T cell receptors, and determine their lineage and optimal conditions of stimulation. To get an idea of the kind of work that will be performed, please refer to: “A conserved human T cell population targets mycobacterial antigens presented by CD1b. Nat Immunol 2013 14(7):706-13.”. While performing research will be the main occupation, the candidate will be expected to assist with teaching. The experimental work will be performed at the Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine at Utrecht University. 

Description

PhD in one of the life sciences or related disciplines; A track record of multiple years of hands-on experience in human immunology; Knowledge of lipid chemistry and purification and experience with human primary T cell culture and analysis are preferred.

Benefits

We offer a temporary full-time appointment of one year with the perspective of prolongation with another 2 years. The gross salary depends on qualifications and experience and ranges between

来源：硕博英才网整理